Hyodeoxycholic acid

Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.

Product Specifications

CAS Number

[83-49-8]

Product Name Alternative

HDCA

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Hyodeoxycholic_acid.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C24H40O4

Molecular Weight

392.57

Precautions

H315, H319, H335

References & Citations

[1]Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51 (6) :1831-41.|[2]Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27 (9) :3805-17.