SOD1-Derlin-1 inhibitor-1
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].
Product Specifications
CAS Number
[840461-03-2]
UNSPSC
12352005
Target
SOD
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sod1-derlin-1-inhibitor-1.html
Purity
99.93
Solubility
DMSO : 2.7 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)
Smiles
NC(C1=CC=C(C2=CN=CC=C2)N=C1S3)=C3C(NC(C=CC(Br)=C4)=C4Br)=O
Molecular Formula
C19H12Br2N4OS
Molecular Weight
504.20
References & Citations
[1]Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9 (1) :2668.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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