SOD1-Derlin-1 inhibitor-1

SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].

Product Specifications

CAS Number

[840461-03-2]

UNSPSC

12352005

Target

SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sod1-derlin-1-inhibitor-1.html

Purity

99.93

Solubility

DMSO : 2.7 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)

Smiles

NC(C1=CC=C(C2=CN=CC=C2)N=C1S3)=C3C(NC(C=CC(Br)=C4)=C4Br)=O

Molecular Formula

C19H12Br2N4OS

Molecular Weight

504.20

References & Citations

[1]Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9 (1) :2668.