Klotho-derived peptide 1 (hydrochloride)
Klotho-derived peptide 1 (KP1 human) hydrochloride blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model[1].
Product Specifications
Product Name Alternative
KP1 (human) (hydrochloride)
UNSPSC
12352209
Target
P38 MAPK; TGF-beta/Smad
Type
Peptides
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/klotho-derived-peptide-1-hydrochloride.html
Purity
98.57
Solubility
0.1 M Acetic acid : 50 mg/mL (adjust pH to 2 with CH3COOH) |H2O : 50 mg/mL (ultrasonic)
Smiles
[Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly(HClsalt)]
Molecular Formula
C149H203N39O43.xHCl
Molecular Weight
3228.44 (free base)
References & Citations
[1]Yuan Q, et al., A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022 Jan 21;13 (1) :438.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
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