Taurocholic acid-d5 (sodium)

Taurocholic acid-d5 (sodium) is deuterium labeled Taurocholic acid (sodium) . Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect[1][2].

Product Specifications

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds; VEGFR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Smiles

O=C(CC[C@H]([C@@]1([C@]2([C@H](C[C@]3([C@@]([H])([C@@H](C[C@@]4(C([2H])([C@@]([2H])(C([2H])(C[C@@]43C)[2H])O)[2H])[H])O)[C@@]2(CC1)[H])[H])O)C)[H])C)NCCS(=O)(O[Na])=O

Molecular Formula

C26H39D5NNaO7S

Molecular Weight

542.72

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Xun Z, et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021 Feb;18 (2) :461-471. |[3]Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15 (2) :217-22.|[4]Glaser S, et al. Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. Dig Liver Dis. 2010 Oct;42 (10) :709-17.