Esculentoside B
Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity[1][2][3].
Product Specifications
CAS Number
60820-94-2
Product Name Alternative
Phytolaccoside B
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Fungal; JNK; NF-κB
Type
Natural Products
Related Pathways
Anti-infection; MAPK/ERK Pathway; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/esculentoside-b.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C([C@@]3([H])[C@](C(O)=O)(CC[C@@](C(OC)=O)(C)C3)CC2)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(C[C@H](O)[C@H](O[C@@]6([H])[C@@H]([C@H]([C@H](O)CO6)O)O)[C@@]5(C)CO)C)C
Molecular Formula
C36H56O11
Molecular Weight
664.82
References & Citations
[1]Abekura F, et al. Esculentoside B inhibits inflammatory response through JNK and downstream NF-κB signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells. Int Immunopharmacol. 2019;68:156-163.|[2]Ren S, et al. Metabolic exploration of the developmental abnormalities and neurotoxicity of Esculentoside B, the main toxic factor in Phytolaccae radix. Food Chem Toxicol. 2023;176:113777. |[3]Escalante A, et al. Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. J Nat Prod. 2008;71 (10) :1720-1725.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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