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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

FGFR; Interleukin Related; NF-κB; NO Synthase; Notch; VEGFR

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation; Neuronal Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-delta-like-protein-4-dll4-antibody-hmd4-2.html

Solubility

10 mM in DMSO

Smiles

[Anti-MouseDelta-likeprotein4/DLL4Antibody(HMD4-2)]

Molecular Weight

(150 kDa)

References & Citations

[1]Remédio L, et al. Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment. PLoS One. 2012;7 (12) :e52450.|[2]Oishi H, et al. Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. Pancreas. 2010 Aug;39 (6) :897-903.|[3]Fukuda D, et al. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012 Jul 3;109 (27) :E1868-77.|[4]Deng Y, et al. Anti-DLL4 ameliorates toluene diisocyanate-induced experimental asthma by inhibiting Th17 response. Int Immunopharmacol. 2021 May;94:107444.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Isoform

FGFR1; IL-1; IL-17; IL-6; iNOS; NF-κB

Frequently Asked Questions

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