Tipepidine (hydrochloride)
Product Specifications
UNSPSC Description
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tipepidine-hydrochloride.html
Purity
99.92
Solubility
DMSO : 41.67 mg/mL (ultrasonic)|H2O : 3.33 mg/mL (ultrasonic)
Smiles
CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
Molecular Weight
311.89
References & Citations
[1]Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34.|[2]Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121685A/Tipepidine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121685A/Tipepidine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1449686-84-3
Available Sizes
Curated Selection
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