Tipepidine (hydrochloride)

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA (GIRK) ) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2].

Product Specifications

CAS Number

[1449686-84-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tipepidine-hydrochloride.html

Purity

99.98

Solubility

DMSO : 41.67 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic)

Smiles

CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl

Molecular Formula

C15H18ClNS2

Molecular Weight

311.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34.|[2]Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.