Crobenetine (hydrochloride)

Crobenetine hydrochloride (BIII-890 hydrochloride) is the hydrochloride form of Crobenetine (HY-16923) . Crobenetine hydrochloride is a selective inhibitor for Na+ channel. Crobenetine hydrochloride displaces 3HBTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, exhibits only low binding affinity for other receptors and ion channels. Crobenetine hydrochloride protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents[1].

Product Specifications

CAS Number

[221018-88-8]

Product Name Alternative

BIII-890 (hydrochloride) ; BIII-890 CL

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/crobenetine-hydrochloride.html

Smiles

OC1=C2C([C@@]3(CCN([C@]([H])(C2)C3(C)C)C[C@H](C)OCC4=CC=CC=C4)C)=CC=C1.Cl

Molecular Formula

C25H34ClNO2

Molecular Weight

416.00

References & Citations

[1]A J Carter, et al. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97 (9) :4944-9.