Ixabepilone
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
Product Specifications
CAS Number
[219989-84-1]
Product Name Alternative
BMS-247550; Aza-epothilone B
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ixabepilone.html
Purity
99.93
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C([C@@H]([C@H]([C@H](CCC[C@]1(O[C@]1(C[C@H](N2)/C(C)=C/C3=CSC(C)=N3)[H])C)C)O)C)C(C)([C@H](CC2=O)O)C
Molecular Formula
C27H42N2O5S
Molecular Weight
506.70
Precautions
H302, H315, H319, H335
References & Citations
[1]John T. Hunt Discovery of Ixabepilone. Mol Cancer Ther February 2009 8; 275
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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