Azoramide

Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR) . Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2].

Product Specifications

CAS Number

[932986-18-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Caspase; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Azoramide.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : ≥ 30 mg/mL

Smiles

CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O

Molecular Formula

C15H17ClN2OS

Molecular Weight

308.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7 (292) :292ra98.|[2]Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11 (2) :130.