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Dexetimide (hydrochloride)

Dexetimide hydrochloride ((+) -Benzetimide hydrochloride) is an antimuscarinic drug with the activity of suppressing neuroleptic-induced Parkinson's syndrome. Dexetimide hydrochloride is used to improve the symptoms of movement disorders caused by the use of neuroleptics. Dexetimide hydrochloride, as the (-) -enantiomer of (-) -Benzetimide, shows the ability to selectively inhibit cholinergic receptors[1].

Product Specifications

CAS Number

21888-96-0

Product Name Alternative

(+) -Benzetimide (hydrochloride) ; (S) - (+) -Dexetimide (hydrochloride) ; Dexbenzetimide (hydrochloride)

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dexetimide-hydrochloride.html

Smiles

O=C1[C@@](C2CCN(CC2)CC3=CC=CC=C3)(C4=CC=CC=C4)CCC(N1)=O.Cl

Molecular Formula

C23H27ClN2O2

Molecular Weight

398.93

References & Citations

[1]Speck AL, et al. The absolute configuration and crystal structure of the anticholinergic drug dexbenzetimide. Nature. 1971 Aug 20;232 (5312) :575-6.|[2]Müller-Gärtner HW, et al. Imaging muscarinic cholinergic receptors in human brain in vivo with Spect, [123I]4-iododexetimide, and [123I]4-iodolevetimide. J Cereb Blood Flow Metab. 1992 Jul;12 (4) :562-70.|[3]Dexetimide: an effective drug for the control of extrapyramidal symptoms induced by pipothiazine palmitate

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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