DJ001
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration[1].
Product Specifications
CAS Number
[2161305-12-8]
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dj001.html
Purity
99.92
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1)/C=C\NC2=CC=CC([N+]([O-])=O)=C2
Molecular Formula
C15H12N2O3
Molecular Weight
268.27
References & Citations
[1]Zhang Y, et al. PTPσ inhibitors promote hematopoietic stem cell regeneration. Nat Commun. 2019 Aug 14;10 (1) :3667.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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