DS1
DS1 is a potent GABAA agonist. DS1 increases the activity of serum response element (SRE) and cAMP response element (CRE) promoters. DS1 induces luteinizing hormone beta (LHbeta) and follicle-stimulating hormone beta (FSHbeta) promoter activity[1].
Product Specifications
CAS Number
372497-52-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ds1.html
Smiles
O=C(NC1=C(C2=CC=CS2)N=C3C(Br)=CC(Br)=CN31)C4=CC=C(Cl)C=C4
Molecular Formula
C18H10Br2ClN3OS
Molecular Weight
511.62
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Mijiddorj T, et al. DS1, a delta subunit-containing GABA (A) receptor agonist, increases gonadotropin subunit gene expression in mouse pituitary gonadotrophs. Biol Reprod. 2015 Feb;92 (2) :45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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