Anti-SODD (NT) Antibody

Rabbit Polyclonal Antibody specific to SODD (NT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

BAG-4, Bcl-2-associated athanogene 4, Silencer of death domains

Gene Name

BAG4

Gene ID

9530

NCBI Gene ID

UniProt

O95429

Accession Number

NP_004865

Cellular Locus

Cytoplasm.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to aa 2-16 of human SODD (accession no. AF111116).

Target Antigen

BAG family molecular chaperone regulator 4

Target

SODD (NT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, ICC, IF

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {PubMed:24270810}.

Additionnal Information

Immunoblotting : use at 1ug/mL. Positive control: HeLa or THP-1 cell lysate. Immunocytochemistry: use at 5ug/mL These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat SODD (60kDa).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

A novel TNF-R1-interacting protein has been identified and designated SODD (silencer of death domains). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF- R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD to engage in the active TNF-R1 complex, thus activating TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RC211251L4V 200 µL

NFKBIL1 (NM_005007) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

49180171 3x 5 nmol

UNC50 siRNA Oligos set (Human)

Ask

View Details

GTR15120414 1 Vial

Lentiviral human TBC1D19 shRNA (UAS) - Lentiviral human TBC1D19 shRNA (UAS) (100)

Ask

View Details