Galanthaminone
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
Product Specifications
CAS Number
510-77-0
Product Name Alternative
(-) -Narwedine; Narwedin
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/galanthaminone.html
Purity
99.85
Solubility
DMSO : 10 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
Molecular Formula
C17H19NO3
Molecular Weight
285.34
Precautions
H301, H311, H331
References & Citations
[1]Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-) -galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463 (3) :321-6.|[2]Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92 (2-3) :147-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
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