Galanthaminone

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Product Specifications

CAS Number

[510-77-0]

Product Name Alternative

(-) -Narwedine; Narwedin

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/galanthaminone.html

Purity

99.85

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24

Molecular Formula

C17H19NO3

Molecular Weight

285.34

Precautions

H301, H311, H331

References & Citations

[1]Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-) -galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463 (3) :321-6.|[2]Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92 (2-3) :147-62.