Biphalin (TFA)
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent[1].
Product Specifications
CAS Number
126872-95-5
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/biphalin-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](N)C(N[C@H](C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(NNC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC3=CC=C(C=C3)O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C46H56N10O10·xC2HF3O2
Molecular Weight
909.00 (free base)
References & Citations
[1]T J Abbruscato, et al. Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives. J Pharmacol Exp Ther. 1996, 276,3.|[2]Redkiewicz P, et al. Biphalin-A Potent Opioid Agonist-As a Panacea for Opioid System-Dependent Pathophysiological Diseases? Int J Mol Sci. 2021 Oct 21;22 (21) :11347.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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