Edonerpic (maleate)
Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ) .
Product Specifications
CAS Number
519187-97-4
Product Name Alternative
T-817 (maleate) ; T-817MA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/edonerpic-maleate.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OC1CN(CCCOCCC2=CC=C3C(C=CS3)=C2)C1.O=C(O)/C=C\C(O)=O
Molecular Formula
C20H25NO6S
Molecular Weight
407.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Hirata K, et al. A novel neurotrophic agent, T-817MA [1-{3-[2- (1-benzothiophen-5-yl) ethoxy] propyl}-3-azetidinol maleate], attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons. J Pharmacol Exp Ther. 2005 Jul;314 (1) :252-9.|[2]Kimura T, et al. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide. Br J Pharmacol. 2009 Jun;157 (3) :451-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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