Edonerpic (maleate)

Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ) .

Product Specifications

CAS Number

[519187-97-4]

Product Name Alternative

T-817 (maleate) ; T-817MA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/edonerpic-maleate.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1CN(CCCOCCC2=CC=C3C(C=CS3)=C2)C1.O=C(O)/C=C\C(O)=O

Molecular Formula

C20H25NO6S

Molecular Weight

407.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Hirata K, et al. A novel neurotrophic agent, T-817MA [1-{3-[2- (1-benzothiophen-5-yl) ethoxy] propyl}-3-azetidinol maleate], attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons. J Pharmacol Exp Ther. 2005 Jul;314 (1) :252-9.|[2]Kimura T, et al. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide. Br J Pharmacol. 2009 Jun;157 (3) :451-63.