Ribostamycin (sulfate)

Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

Product Specifications

CAS Number

[53797-35-6]

Product Name Alternative

Vistamycin (sulfate)

UNSPSC

12352005

Hazard Statement

H312, H332, H360

Target

Antibiotic; Bacterial; PDI

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ribostamycin-sulfate.html

Purity

99.55

Solubility

DMSO : < 1 mg/mL|H2O : 130 mg/mL (ultrasonic)

Smiles

O=S(O)(O)=O.O[C@@H]([C@H](O)[C@@H](CN)O1)[C@@H](N)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@@]2([H])O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

Molecular Formula

C17H36N4O14S

Molecular Weight

552.55

Precautions

H312, H332, H360

References & Citations

[1]Baud H, et al. Ribostamycin, as an intermediate in the biosynthesis of neomycin. J Antibiot (Tokyo) . 1977 Sep;30 (9) :720-3.|[2]Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17 (3) :203-8.|[3]Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289 (5) :967-72.