Nimesulide (Standard)
Nimesulide (Standard) is the analytical standard of Nimesulide. This product is intended for research and analytical applications. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM) . Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
Product Specifications
CAS Number
51803-78-2
Product Name Alternative
R805 (Standard)
UNSPSC
12352005
Hazard Statement
H301
Target
COX; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/nimesulide-standard.html
Smiles
CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2=CC=CC=C2)=O
Molecular Formula
C13H12N2O5S
Molecular Weight
308.31
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45 (10) :1096-8.|[2]Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543 (1-3) :181-9.|[3]Genç S, et al. The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. Clin Exp Med. 2007 Mar;7 (1) :6-10.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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