GW701427A

GW701427A is a dual inhibitor of Fluc and VEGFR2 with IC50 of 0.12 μM and 603 nM, respectively. GW701427A acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential implications for Fluc reporter assays[1].

Product Specifications

CAS Number

[433224-56-7]

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/gw701427a.html

Solubility

10 mM in DMSO

Smiles

COC(NC1=NC2=C(N1)C=CC(OC3=CC=C(NC(NC4=CC=CC(C(O)=O)=C4)=O)C=C3)=C2)=O

Molecular Formula

C23H19N5O6

Molecular Weight

461.43

References & Citations

[1]Dranchak P, et al. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8 (3) :e57888.