Halazone
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water[1][2].
Product Specifications
CAS Number
80-13-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Carbonic Anhydrase; Sodium Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/halazone.html
Purity
75.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(S(=O)(N(Cl)Cl)=O)C=C1
Molecular Formula
C7H5Cl2NO4S
Molecular Weight
270.09
Precautions
H302, H315, H319, H335
References & Citations
[1]M Rack, et al. Effects of Some Chemical Reagents on Sodium Current Inactivation in Myelinated Nerve Fibers of the Frog. Biophys J. 1986 Oct;50 (4) :557-64.|[2]Rema Iyer, et al. Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds. J Biomol Screen. 2006 Oct;11 (7) :782-91.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CA II
Available Sizes
Frequently Asked Questions
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