4-Methylcinnamic acid
4-Methylcinnamic acid is a cinnamic acid derivative with antifungal activity. 4-Methylcinnamic acid can overcome the tolerance of glutathione reductase mutants to 4-Methoxycinnamic acid (HY-N1387) . When 4-Methylcinnamic acid is used in combination with traditional antifungal agents, it can reduce their minimum inhibitory concentrations. 4-Methylcinnamic acid can act as an intervention catalyst to enhance the efficacy of traditional antifungal agents and has application potential in targeting fungal cell wall disruption and controlling drug-resistant fungi[1].
Product Specifications
CAS Number
[1866-39-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/3-_p-Tolyl_acrylic_acid.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C=CC(O)=O)C=C1
Molecular Formula
C10H10O2
Molecular Weight
162.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim JH, et, al. Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance. Molecules. 2017 Oct 21;22 (10) :1783.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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