LAVR-289
Product Specifications
CAS Number
2379824-89-0
UNSPSC Description
LAVR-289 is a [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with broad-spectrum anti-DNA virus activity. LAVR-289 can inhibit the activity of the wild-type (TK+) of varicella-zoster virus (VZV), thymidine kinase VZV-defective strain, human cytomegalovirus (HCMV), vaccinia virus (VV), and human herpesvirus 1 (HSV-1) (TK-) with EC50 values of 3.5 nM, 18 nM, 21 nM, 50 nM, and 8.5 nM, respectively[1].
Target Antigen
HSV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lavr-289.html
Solubility
10 mM in DMSO
Smiles
CC(OC/C(COC1=NC(N)=NC(N)=C1)=C\CP(OCOC(OC(C)C)=O)(OCCCOCCCCCCCCCCCCCCCC)=O)=O
Molecular Weight
730.87
References & Citations
[1]Bessières M, et al. Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses. Eur J Med Chem. 2024;271:116412.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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