BAY-293

BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1) . SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1].

Product Specifications

CAS Number

[2244904-70-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ras; SOS1

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BAY-293.html

Purity

98.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C=C(N=C(C)N=C2N[C@H](C)C3=CC(C4=C(CNC)C=CC=C4)=CS3)C2=C1

Molecular Formula

C25H28N4O2S

Molecular Weight

448.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116 (7) :2551-2560.