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K-Ras ligand-Linker Conjugate 6

Product Specifications

UNSPSC Description

K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

Target Antigen

Target Protein Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/k-ras-ligand-linker-conjugate-6.html

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCN)C6)=N2)CC1)OC(C)(C)C

Molecular Weight

788.98

References & Citations

[1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-130991/K-Ras-ligand-Linker-Conjugate-6-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-130991/K-Ras-ligand-Linker-Conjugate-6-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2378261-89-1

Available Sizes

Curated Selection

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