N-Nitrosodibutylamine

N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water. N-Nitrosodibutylamine regulates caspase pathway. N-Nitrosodibutylamine induces Apoptosis. N-Nitrosodibutylamine induces hepatocarcinoma and oxidative DNA damage[1][2][3][4][5].

Product Specifications

CAS Number

[924-16-3]

Product Name Alternative

N-Nitroso-di-n-butylamine

UNSPSC

12352211

Hazard Statement

H302, H351

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-nitrosodibutylamine.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCN(CCCC)N=O

Molecular Formula

C8H18N2O

Molecular Weight

158.24

Precautions

H302, H351

References & Citations

[1]Chao Zhao, et al. Distribution of N-nitrosamines in Drinking Water and Human Urinary Excretions in High Incidence Area of Esophageal Cancer in Huai'an, China. Chemosphere. 2019 Nov;235:288-296.|[2]García A, et al. N-Nitrosopiperidine and N-Nitrosodibutylamine induce apoptosis in HepG2 cells via the caspase dependent pathway. Cell Biol Int. 2009 Dec;33 (12) :1280-6.|[3]García A, et al. Organosulfur compounds alone or in combination with vitamin C protect towards N-nitrosopiperidine- and N-nitrosodibutylamine-induced oxidative DNA damage in HepG2 cells. Chem Biol Interact. 2008 May 9;173 (1) :9-18.|[4]Brittebo EB, et al. Tissue-specificity of N-nitrosodibutylamine metabolism in Sprague-Dawley rats. Chem Biol Interact. 1982 Jan;38 (2) :231-42.|[5]Dutta S P, et al. Effects of N-Nitrosodibutylamine on the liver mitochondria morphology and on the expression of liver mitochondrial membrane surface proteins in mice. International Journal of Pharmacy and Pharmaceutical Sciences, (8), 2016: 162-168.