Sapanisertib

Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.

Product Specifications

CAS Number

[1224844-38-5]

Product Name Alternative

INK-128; MLN0128; TAK-228

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; mTOR

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/INK-128.html

Purity

99.78

Solubility

DMSO : 55 mg/mL (ultrasonic)

Smiles

NC1=NC=NC2=C1C(C3=CC4=C(C=C3)OC(N)=N4)=NN2C(C)C

Molecular Formula

C15H15N7O

Molecular Weight

309.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu A, et al. mTOR Mediated Anti-Cancer Drug Discovery. Drug Discovery Today: Therapeutic Strategies. 2009, 6 (2), 47-55.|[2]Hsieh AC, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22;485 (7396) :55-61.