PKL-IN-1

PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease[1].

Product Specifications

UNSPSC

12352005

Target

Pyruvate Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pkl-in-1.html

Purity

99.36

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=C(C(C(O)=C(O)C(O)=C2)=C2OS3(=O)=O)C3=C1

Molecular Formula

C12H8O8S

Molecular Weight

312.25

References & Citations

[1]Matić J, et al. Sulfone-based human liver pyruvate kinase inhibitors - Design, synthesis and in vitro bioactivity. Eur J Med Chem. 2024;269:116306.