Azatadine (dimaleate)

Azatadine dimaleate (Azatadine maleate) is an inhibitor of histamine and cholinergic with an IC50 of 6. Azatadine dimaleate has additional antiserotonin activity. Azatadine dimaleate can be studied in research on perennial allergic rhinitis[1][2].

Product Specifications

CAS Number

[3978-86-7]

Product Name Alternative

Azatadine maleate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Azatadine-dimaleate.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

Smiles

O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C4\2

Molecular Formula

C28H30N2O8

Molecular Weight

522.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Wilson JD, et al. Azatadine maleate (Zadine) : evaluation in the management of allergic rhinitis. N Z Med J. 1981 Aug 12;94 (689) :79-81.|[2]Tozzi S, et al. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions. 1974 Oct;4 (4) :264-70.|[3]B. Biehl, et al., Effects of azatadine maleate on subjective appraisal and psychomotor functions relevant to driving performance. Current Medical Research and Opinion, 1979.|[4]JL Hillas, et al., Azatadine maleate in perennial allergic rhinitis: effects on clinical symptoms and choice reaction time. British journal of clinical pharmacology, 1980.