HDAC6 degrader-1

HDAC6 degrader-1 (Compound NP8) is the PROTAC degrader for HDAC6 with a DC50 of 3.8 nM in cell MM.1S[1]. (Blue: ligand for E3 ligase Pomalidomide (HY-10984) ; Black: linker (HY-140213) ; Pink: ligand for target protein Nexturastat A (HY-16699) )

Product Specifications

CAS Number

[2439058-23-6]

UNSPSC

12352005

Target

HDAC; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac6-degrader-1.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(CN(CCCCC2=CN(CCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1)NO

Molecular Formula

C40H45N9O9

Molecular Weight

795.84

References & Citations

[1]An Z, et al. Developing potent PROTACs tools for selective degradation of HDAC6 protein [published correction appears in Protein Cell. 2019 Feb 22; :]. Protein Cell. 2019;10 (8) :606-609.