PDGFRα kinase inhibitor 2
PDGFRα kinase inhibitor 2 (compound 1), an Imatinib analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt[1].
Product Specifications
CAS Number
404844-11-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bcr-Abl; c-Kit; PDGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdgfrα-kinase-inhibitor-2.html
Purity
98.95
Solubility
DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2
Molecular Formula
C24H20ClN5O
Molecular Weight
429.90
Precautions
H302, H315, H319, H335
References & Citations
[1]Emeline Leproult, et al. Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54 (5) :1347-55.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl; PDGFR
Available Sizes
Frequently Asked Questions
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