PDGFRα kinase inhibitor 2

PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt[1].

Product Specifications

CAS Number

[404844-11-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bcr-Abl; c-Kit; PDGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdgfrα-kinase-inhibitor-2.html

Purity

98.95

Solubility

DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2

Molecular Formula

C24H20ClN5O

Molecular Weight

429.90

Precautions

H302, H315, H319, H335

References & Citations

[1]Emeline Leproult, et al. Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54 (5) :1347-55.