Nav1.7-IN-13
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine -induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity[1].
Product Specifications
CAS Number
2776235-57-3
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-7-in-13.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C/CN1C2=CC(Br)=CC=C2[C@@]([C@]3(C(OC)=O)OC(C=CC=C4)=C4C3)(O)C1=O
Molecular Formula
C23H22BrNO5
Molecular Weight
472.33
References & Citations
[1]Wang Y, et al. Nav1.7 Modulator Bearing a 3-Hydroxyindole Backbone Holds the Potential to Reverse Neuropathic Pain. ACS Chem Neurosci. 2024 Mar 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
GABA A Receptor beta 2 + 3 Rabbit Polyclonal Antibody (PerCP-Cy5.5)
