Phosphocreatine (dipotassium)

Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway.[1][2][3][4].

Product Specifications

CAS Number

[18838-38-5]

Product Name Alternative

Creatine phosphate (dipotassium) ; Creatinephosphoric acid (dipotassium)

UNSPSC

12352211

Target

Akt; Apoptosis; Endogenous Metabolite; ERK; MAP3K; Mitochondrial Metabolism; ROS Kinase

Type

Natural Products

Related Pathways

Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/phosphocreatine-dipotassium.html

Solubility

10 mM in DMSO

Smiles

OC(CN(C(NP(O[K])(O[K])=O)=N)C)=O

Molecular Formula

C4H8K2N3O5P

Molecular Weight

287.29

References & Citations

[1]Feldman EB, et al. Creatine: a dietary supplement and ergogenic aid. Nutr Rev. 1999 Feb;57 (2) :45-50.|[2]Wang C, et al. Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro. Toxicology. 2021 Aug;460:152881. |[3]Li H, et al. Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med. 2018 May 20;120:228-238.|[4]Shopit A, et al. Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway. Life Sci. 2020 Feb 1;242:117248.