ENMD-2076 (Tartrate)
ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
Product Specifications
CAS Number
1453868-32-0
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase; FGFR; FLT3; PDGFR; Src; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/enmd-2076-tartrate.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C([C@@H]([C@H](C(O)=O)O)O)O.CC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(CC4)C)=C2)=NN1
Molecular Formula
C25H31N7O6
Molecular Weight
525.56
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Aurora A; PDGFRα; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Citation 01
Available Sizes
Frequently Asked Questions
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