NBD-Pen

NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λex: 470 nm, λem: 530 nm) . NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H2O2, ClO-, O2-∙, and ∙OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma[1].

Product Specifications

CAS Number

[1955505-54-0]

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nbd-pen.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[O]N1C(C)(C)CC(NC2=CC=C([N+]([O-])=O)C3=NON=C32)CC1(C)CCCCC

Molecular Formula

C19H28N5O4?

Molecular Weight

390.46

References & Citations

[1]Ishida Y, et al. Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Free Radic Biol Med. 2017 Dec;113:487-493.|[2]Yamada, K., et al., (2016) . Fluorescence probes to detect lipid-derived radicals. Nature chemical biology, 12 (8), 608–613.