Phorbol
Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo[1][2][3].
Product Specifications
CAS Number
17673-25-5
Product Name Alternative
4β-Phorbol
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Phorbol.html
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 20 mg/mL
Smiles
O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(O)[C@H](O)[C@H]3C)([H])C=C(CO)C[C@]12O
Molecular Formula
C20H28O6
Molecular Weight
364.43
Precautions
H315, H319
References & Citations
[1]Kawamura, S., et al., (2016) . Nineteen-step total synthesis of (+) -phorbol. Nature, 532 (7597), 90–93. |[2]Montesano, R., & Orci, L. (1985) . Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell, 42 (2), 469–477.|[3]Blumberg P. M. (1980) . In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Critical reviews in toxicology, 8 (2), 153–197.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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