Phorbol

Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo[1][2][3].

Product Specifications

CAS Number

[17673-25-5]

Product Name Alternative

4β-Phorbol

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Phorbol.html

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 20 mg/mL

Smiles

O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(O)[C@H](O)[C@H]3C)([H])C=C(CO)C[C@]12O

Molecular Formula

C20H28O6

Molecular Weight

364.43

Precautions

H315, H319

References & Citations

[1]Kawamura, S., et al., (2016) . Nineteen-step total synthesis of (+) -phorbol. Nature, 532 (7597), 90–93. |[2]Montesano, R., & Orci, L. (1985) . Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell, 42 (2), 469–477.|[3]Blumberg P. M. (1980) . In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Critical reviews in toxicology, 8 (2), 153–197.