DCPT1061 (hydrochloride)
DCPT1061 hydrochloride has a strong inhibitory effect on PRMT1, PRMT6, and PRMT8 in vitro, The epigenetic enzymes such as PRMT3, PRMT4 and PRMT5 had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects[1][2].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dcpt1061-hydrochloride.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=C(OC2=CC=CC=C2CN(C)CCNC)C=CC=C1Cl.[H]Cl
Molecular Formula
C17H21Cl3N2O
Molecular Weight
375.72
References & Citations
[1]Wang J, et al. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Theranostics. 2021 Mar 12;11 (11) :5387-5403.|[2]Tao H, et al. PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma. Cancer Res. 2023 Nov 22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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