Py-BODIPY-NHS ester

BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions[1]. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells[2].

Product Specifications

CAS Number

[201998-61-0]

UNSPSC

12171500

Hazard Statement

H315, H319

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/energy-transfer-probe-1.html

Purity

98.98

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

[F-][B+3]1([N]2=C(C3=CC=CN3)C=CC2=CC4=CC=C(CCC(ON(C5=O)C(CC5)=O)=O)[N-]14)[F-]

Molecular Formula

C20H17BF2N4O4

Molecular Weight

426.18

Precautions

H315, H319

References & Citations

[1]Vasta JD, et al. Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of CellularATP on Target Engagement. Cell Chem Biol. 2018 Feb 15;25 (2) :206-214.e11.|[2]Yuan H, et al. Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chem Commun (Camb) . 2013 Nov 14;49 (88) :10361-3.|[3]Robers MB, et al. Quantitative, Real-Time Measurements of Intracellular Target Engagement Using Energy Transfer. Methods Mol Biol. 2019;1888:45-71.|[4]Kamkaew A, et al. BODIPY dyes in photodynamic therapy. Chem Soc Rev. 2013 Jan 7;42 (1) :77-88.|[5]Kang ZB, et al. Fluopack screening platform for unbiased cellular phenotype profiling. Sci Rep. 2020 Feb 7;10 (1) :2097.