MTOR inhibitor WYE-28
MTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/bIC50) =0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].
Product Specifications
CAS Number
[1062172-60-4]
Product Name Alternative
WYE-125132
UNSPSC
12352005
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-wye-28.html
Purity
99.75
Solubility
DMSO : 60 mg/mL (ultrasonic; warming)
Smiles
O=C(N1CCC(N2N=CC3=C(N=C(N=C32)C4=CC=C(C=C4)NC(NC5=CC=C(C=C5)CO)=O)N6CCOCC6)CC1)OC
Molecular Formula
C30H34N8O5
Molecular Weight
586.64
References & Citations
[1]Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52 (16) :5013-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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