Helenalin acetate

Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1].

Product Specifications

CAS Number

[10180-86-6]

UNSPSC

12352005

Target

Histone Demethylase; NF-κB

Type

Reference compound

Related Pathways

Epigenetics; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/helenalin-acetate.html

Purity

99.55

Solubility

10 mM in DMSO

Smiles

CC(O[C@@H]1[C@]2([C@](C=CC2=O)([H])[C@@H](C[C@@H]3[C@H]1C(C(O3)=O)=C)C)C)=O

Molecular Formula

C17H20O5

Molecular Weight

304.34

References & Citations

[1]Jakobs A, et al. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300. J Biol Chem. 2016 Dec 9;291 (50) :26098-26108.