PCSK9 rabbit pAb

Cofactor: Calcium. Disease: Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM: 603776]. FH3 inheritance is autosomal dominant. enzyme regulation: Inhibited by EGTA. function: May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. similarity: Belongs to the peptidase S8 family. similarity: Contains 1 peptidase S8 domain. subunit: The precursor protein but not the mature protein may form multimers. tissue specificity: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

Product Specifications

Background

Cofactor:Calcium., disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant., enzyme regulation:Inhibited by EGTA., function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis., PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme., similarity:Belongs to the peptidase S8 family., similarity:Contains 1 peptidase S8 domain., subunit:The precursor protein but not the mature protein may form multimers., tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

UniProt

Q8NBP7

Swiss Prot

Q8NBP7

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human PCSK9

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.

Other Product Names

Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-; Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9)