Perhexiline-d11 (maleate)
Perhexiline-d11 (maleate) is the deuterium labeled Perhexiline maleate. Perhexiline maleate is a potent carnitine palmitoyltransferase 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively.
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Mitochondrial Metabolism
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[2H]C1([2H])C(C(C2CCCCC2)CC3NCCCC3)([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H].O=C(O)/C=C\C(O)=O
Molecular Formula
C23H28D11NO4
Molecular Weight
404.63
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kennedy JA, et al. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by Perhexiline and amiodarone. Biochem Pharmacol. 1996 Jul 26;52 (2) :273-80.|[3]Vella S, et al. Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA. Sci Rep. 2015 Dec 17;5:18144.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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