(S, S, S) -AHPC (hydrochloride)

(S, S, S) -AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S, S, S) -AHPC (Compound 27) is a ligand used as a negative control for (S, R, S) -AHPC. (S, R, S) -AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].

Product Specifications

CAS Number

[2115897-23-7]

Product Name Alternative

(S, S, S) -VH032-NH2 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-s-s-ahpc-hydrochloride.html

Purity

99.16

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](C[C@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl

Molecular Formula

C22H31ClN4O3S

Molecular Weight

467.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61 (2) :583-598.