NADP

NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].

Product Specifications

CAS Number

[53-59-8]

Product Name Alternative

DDD00107587

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NADP.html

Purity

99.70

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O1)([O-])OP(OC[C@H]3O[C@@H](N4C5=NC=NC(N)=C5N=C4)[C@H](OP(O)(O)=O)[C@@H]3O)(O)=O

Molecular Formula

C21H28N7O17P3

Molecular Weight

743.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen L, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125.|[2]Nam TS, et al. Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration. FASEB J. 2020 Sep;34 (9) :12565-12576. |[3]Ilter D, et al. NADK-mediated de novo NADP (H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. |[4]Lee SH, et al. Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells. 2010 Feb 28;29 (2) :203-8.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Citation 01

Cell Oncol (Dordr) . 2023 Jun;46 (3) :761-776.|Insect Biochem Mol Biol. 2023 Jun:157:103958.|World J Microbiol Biotechnol. 2024 Oct 19;40 (11) :357.|Cell Prolif. 2021 Apr;54 (4) :e13015.|Eur J Pharm Sci. 2023 Aug 1:187:106475.|FASEB J. 2024 Jul 31;38 (14) :e23844.