Lergotrile (mesylate)
Product Specifications
UNSPSC Description
Lergotrile mesylate is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile mesylate inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile mesylate has the potential for the research of Parkinson's disease[1][2][3].
Target Antigen
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lergotrile-mesylate.html
Smiles
CS(=O)(O)=O.ClC1=C2C3=C(N1)C=CC=C3[C@]4([H])[C@@](N(C[C@@H](C4)CC#N)C)([H])C2
Molecular Weight
395.90
References & Citations
[1]Clemens JA, et al. Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action. Acta Endocrinol (Copenh). 1975 Jun;79(2):230-7. |[2]Lemberger L, et al. The inhibitory effect of an ergoline derivative (lergotrile, compound 83636) on prolactin secretion in man. J Clin Endocrinol Metab. 1974 Sep;39(3):579-84.|[3]Lieberman A, et al. Treatment of Parkinson's disease with lergotrile mesylate. JAMA. 1977 Nov 28;238(22):2380-2.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107002A/Lergotrile-mesylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107002A/
Clinical Information
No Development Reported
CAS Number
51473-23-5
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