TCS 401
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) .
Product Specifications
CAS Number
243966-09-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/TCS-401.html
Purity
98.0
Solubility
0.1 M NaOH : 6.67 mg/mL (ultrasonic; adjust pH to 9 with NaOH)
Smiles
O=C(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)O.[H]Cl
Molecular Formula
C10H11ClN2O5S
Molecular Weight
306.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31.|[2]Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304 (6) :F698-709.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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